This guide is a tool to assist farmers in understanding the complex framework of laws surrounding the planting of genetically modified organisms (GMOs). The guide explains farmers’ legal obligations under GMO contracts and the very real possibility that farmers may be held legally liable to pay tens of thousands of dollars to biotech companies for violations of those contracts or to neighboring farmers whose fields become contaminated with GMOs. It also highlights the devastating impact GMO contamination has had on some agricultural markets and the lawsuits surrounding those events. Due to the significant risks posed by planting GMOs, the guide provides some suggestions on how farmers may protect themselves from GMO contamination risks.